Flibanserin

Igoa vaila'au:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

SMILES Code:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

InChi Code:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

upu autu:

Flibanserin, 167933-07-5

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

Flibanserin o se agonist atoatoa o le 5-HT1A receptor (Ki = 1 nM) ma, faʻatasi ai ma le vavalalata maualalo, o se faʻalavelave o le 5-HT2A receptor (Ki = 49 nM) ma le antagonist poʻo le vaivai vaega agonist o le D4 receptor ( Ki = 4–24 nM). E ui lava i le tele o fesoʻotaʻiga o le flibanserin mo le 5-HT1A faʻafeiloaʻi, ma mo mafuaʻaga e le o iloa, o le flibanserin o loʻo nofoia le 5-HT1A ma le 5-HT2A tali i vivo ma tutusa pasene. O le Flibanserin e maualalo foi le vavalalata mo le 5-HT2B receptor (Ki = 89.3 nM) ma le 5-HT2C receptor (Ki = 88.3 nM), o ia mea uma e lua e amio o se tagata tetee. Flibanserin e sili ona faʻagaoioia 5-HT1A faʻafeiloaʻi i le pito i luma o le cortex, faʻaalia le filifilia faʻaitulagi, ma ua maua e faʻateleina le maualuga o le dopamine ma le norepinephrine ma faʻaitiitia ai le serotonin maualuga i le rat prefrontal cortex, o gaioiga na faʻamoemoe e faʻatalanoaina e ala i le faʻagaoioia o le 5-HT1A. talitali.[12] E pei o lea, o le flibanserin ua faʻamatalaina o se norepinephrine-dopamine disinhibitor (NDDI). Flibanserin na faʻamaonia ia Aukuso 2015 mo togafitiga o fafine aʻo leʻi faʻataʻitaʻiina fafine ma le faʻafitauli o le manaʻoga feusuaʻi (HSDD).

Sini: 5HT