E-7046

Igoa vaila'au:

(S)-4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid

SMILES Code:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F)=O)C)C=C1

InChi Code:

InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2 )20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32) ,33)/t11-/m0/s1

InChi Key:

MKLKAQMPKHNQPR-NSHDSACASA-N

upu autu:

E-7046, E7046, E 7046, 1369489-71-3

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

I le CT-26 tumo faʻataʻitaʻiga, o le E7046/RT tuʻufaʻatasiga e mafua ai le tali atu o le manatua o manu e 9. I le 4T1 faʻataʻitaʻiga, o le tuʻufaʻatasiga o le E7046 ma le RT e maua ai le sili atu o le faʻalavelave faʻatupulaia o le tumo pe a faʻatusatusa i togafitiga taʻitasi. O le tuʻufaʻatasiga e faʻaleleia atili ai le ola e ala i le taofiofia o le metastasis o le mama faʻafuaseʻi o le 4T1 tuma [1]. E7046 (150 mg / kg) faʻalavelaveina le tuputupu aʻe o le tele o faʻataʻitaʻiga tumo syngeneic. O le poloka o le faailo EP4 e faʻamalosia ai le eseesega o le tumo DC ma faʻagesegese le tuputupu aʻe o le toto i isumu. O le togafitiga E7046 e fa'aitiitia ai le tuputupu a'e po'o le teena fo'i o tumo fa'amautu i vivo i se faiga fa'alagolago ile myeloid ma le CD8C T sela. E le gata i lea, o le pulega faʻatasi o le E7046 ma le E7777, o le IL-2-diphtheria toxin fusion protein e sili ona faʻaumatia Tregs, faʻalavelave faʻafuaseʻi le myeloid ma Treg immunosuppressive networks, e mafua ai le lelei ma le umi o le anti-tumour immune responses i faʻataʻitaʻiga tumo o isumu [2] .

Sini: EP4