BI-3406
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 0.5g | E tele | 850 |
| 1g | E tele | 1450 |
| 5g | E tele | 6200 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amine
SMILES Code:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2
InChi Code:
InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11- 17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3,(H,28,29 ,30)/t12-,17+/m1/s1
InChi Key:
XVFDNRYZXDHHTT-PXAZEXFGSA-N
upu autu:
BI-3406; BI 3406; BI3406
Solubility:
Teuina:
Fa'amatalaga:
BI-3406 o le SOS1 Potent & Selective :: KRAS Inhibitor (IC50=5 nM), lea e tatalaina ai se auala fou mo le togafitia o le KRAS-Driven Tumours. BI 3406 filifili fa'atasi i le SOS1 ma poloka le feso'ota'iga ma KRAS, tusa lava po'o le KRAS mutation. O le BI 3406 e mafua ai le RAS GTP ma le pERK faʻaitiitia ma faʻalavelaveina le tuputupu aʻe o sela o KRAS laina faʻasolosolo, o loʻo tauaveina le tele o suiga masani KRAS (ie G12D, G12V, G13D ma isi). BI 3406, pe a tuʻuina tautala i isumu o loʻo i ai le tuma, e mafua ai se aafiaga faʻalagolago i le tumo e mafai ona liua i faʻasalaga pe a tuʻufaʻatasia ma MEK1 faʻasaina.
Sini: SOS1
