BMS-986165
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 10mg | E tele | 260 |
| 100mg | E tele | 530 |
| 1g | E tele | 1350 |
Igoa vaila'au:
6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 -carboxamide
SMILES Code:
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]
InChi Code:
InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3
InChi Key:
BZZKEPGENYLQSC-FIBGUPNXSA-N
upu autu:
1609392-27-9；CAS:1609392-27-9；CAS:1609392-27-9；BMS-986165; BMS 986165; BMS986165; Deucravacitinib
Solubility:Solu i le DMSO
Teuina:Mago, pogisa ma i le 0 - 4 C mo taimi pupuu (aso i vaiaso) po'o le -20 C mo taimi uumi (masina i tausaga).
Fa'amatalaga:
O le BMS-986165 o se mea e sili ona malosi ma filifili le Allosteric Inhibitor o TYK2. BMS-986165 Blocks Il-12, IL-23 ma le ituaiga I Interferon Signaling ma tuʻuina atu mo le malosi malosi i faʻataʻitaʻiga faʻapitoa o faʻamaʻi inflammatory bowel. MS-986165 malosi e fusifusia i le Tyk2 pseudokinase domain (Ki = 0.02 nM), ma e sili ona filifilia e faasaga i se laulau o 265 kinases ma pseudokinases. O le mea fa'apipi'i na fa'alavelaveina IL-23-, IL-12-, ma le Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM).
Sini: TYK2
