TAS-120

Izina ryimiti:

1 - [(3S) -3- [4-amino-3- [2- (3,5-dimethoxyphenyl) ethynyl] -1H-pyrazolo -2-propen-1-imwe

Kode ya SMILES:

C = CC (N1C [C @@ H] (N2N = C (C # CC3 = CC (OC) = CC (OC) = C3) C4 = C (N) N = CN = C42) CC1) = O

InChi Code:

InChI = 1S / C22H22N6O3 / c1-4-19 (29) 27-8-7-15 (12-27) 28-22-20 (21 (23) 24-13-25-22) 18 (26-28) 6-5-14-9-16 (30-2) 11-17 (10-14) 31-3 / h4,9-11,13,15H, 1,7-8,12H2,2-3H3, (H2 , 23,24,25) / t15- / m0 / s1

InChi Urufunguzo:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

Ijambo ryibanze:

TAS-120

Gukemura: 

Ububiko: 

Ibisobanuro:

TAS-120 ni bioavailable yo mu kanwa ibuza fibroblast gukura kwakirwa (FGFR) hamwe nibikorwa bya antineoplastique. Inzitizi ya FGFR TAS-120 ihitamo kandi idasubirwaho ihuza kandi ikabuza FGFR, ibyo bikaba bishobora kuviramo guhagarika inzira yo gukwirakwiza ibimenyetso byifashishijwe na FGFR hamwe no gukwirakwiza ibibyimba, ndetse no kongera urupfu rw'uturemangingo muri selile yibibyimba ya FGFR-bikabije. FGFR ni reseptor tyrosine kinase ikenewe mugukwirakwiza kanseri yibibyimba, gutandukana no kubaho kandi imvugo yayo igengwa nubwoko bwinshi bwibibyimba.

Intego: FGFR