PRT-060318; PRT318; P142–76

Izina ryimiti:

2 - ((((1R, 2S) -2-aminocyclohexyl) amino) -4- (m-tolylamino) pyrimidine-5-carboxamide

Kode ya SMILES:

O = C (C1 = CN = C (N [C @ H] 2 ​​[C @@ H] (N) CCCC2) N = C1NC3 = CC = CC (C) = C3) N

InChi Code:

InChI = 1S / C18H24N6O / c1-11-5-4-6-12 (9-11) 22-17-13 (16 (20) 25) 10-21-18 (24-17) 23-15-8- 3-2-7-14 (15) 19 / h4-6,9-10,14-15H, 2-3,7-8,19H2,1H3, (H2,20,25) (H2,21,22, 23,24) / t14-, 15 + / m0 / s1

InChi Urufunguzo:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

Ijambo ryibanze:

PRT-060318, PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

PRT060318 ninzitizi ikomeye kandi ihitamo inhibitori ya spleen tyrosine kinase (Syk; IC50 = 4 nM) .Birahitamo, bibuza 92% byibikorwa bya Syk, mugihe izindi kinase zigumana> 70%, murwego rwa 50 nM mukibaho 270 kinase. PRT060318 irabuza guterana kwa konulxine iterwa na plasma ikungahaye kuri platine (IC50 = 2,5 μM) muri vitro kandi ikarinda trombose muburyo bwimbeba yimbeba ya heparin iterwa na trombocytopenia. Itera lymphocytike idakira (CLL) B selile apoptose kandi ikabuza gusohora chemokine CCL3, CCL4, na CXCL13.3 PRT060318 nayo ibuza chemotaxis ya CLL B na pseudoemperipolesis.

Intego: Syk