BAY 61-3606 2HCl

Izina ryimiti:

2 - [[7- (3,4-Dimethoxyphenyl) imidazo

Kode ya SMILES:

O = C (N) C1 = C (NC2 = NC (C3 = CC = C (OC) C (OC) = C3) = CC4 = NC = CN24) N = CC = C1. [H] Cl. [H] Cl

InChi Code:

InChI = 1S / C20H18N6O3.2ClH / c1-28-15-6-5-12 (10-16 (15) 29-2) 14-11-17-22-8-9-26 (17) 20 (24- 14) 25-19-13 (18 (21) 27) 4-3-7-23-19 ;; / h3-11H, 1-2H3, (H2,21,27) (H, 23,24,25) ; 2 * 1H

InChi Urufunguzo:

SPMFEULFGGPQLN-UHFFFAOYSA-N

Ijambo ryibanze:

BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

BAY 61-3606 nimbaraga (Ki = 7.5 nM) hamwe na inhibitor ya Syk kinase. BAY 61-3606 ntiyabujije gusa gutesha agaciro (indangagaciro za IC50 hagati ya 5 na 46 nM) ahubwo yanabujije umuhuza wa lipid hamwe na synthesis ya cytokine muri selile. BAY 61-3606 yari ifite imbaraga nyinshi muri basofile yakuwe mubintu bizima byabantu (IC50 = 10 nM) kandi bisa nkaho byibuze bifite imbaraga muri basofili yakuwe mubintu bya atopic (serumu yo hejuru IgE) (IC50 = 8.1 nM). B yakira reseptor ya selile na reseptor ya Fc igice cya IgG amarenga muri eosinofile na monocytes nayo yahagaritswe cyane na BAY 61-3606.

Intego: Syk