BI-3406
Ibicuruzwa birambuye
Ibicuruzwa
| Ingano | Kuboneka | Igiciro (USD) |
| 0.5g | Mububiko | 850 |
| 1g | Mububiko | 1450 |
| 5g | Mububiko | 6200 |
| Ingano nini | Shaka Amagambo | Shaka Amagambo |
Izina ryimiti:
N - ((R) -1- (3-amino-5- (trifluoromethyl) phenyl) ethyl) -7-mikorerexy-2-methyl-6 - (((S) -tetrahydrofuran-3-yl) oxy) quinazolin- 4-amine
Kode ya SMILES:
C [C @ H] (C1 = CC (N) = CC (C (F) (F) F) = C1) NC2 = C3C (C = C (OC) C (O [C @ H] 4CCOC4) = C3 ) = NC (C) = N2
InChi Code:
InChI = 1S / C23H25F3N4O3 / c1-12 (14-6-15 (23 (24,25) 26) 8-16 (27) 7-14) 28-22-18-9-21 (33-17-4- 5-32-11- 17) 20 (31-3) 10-19 (18) 29-13 (2) 30-22 / h6-10,12,17H, 4-5,11,27H2,1-3H3, (H, 28,29 , 30) / t12-, 17 + / m1 / s1
InChi Urufunguzo:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Ijambo ryibanze:
BI-3406; BI 3406; BI3406
Gukemura:
Ububiko:
Ibisobanuro:
BI-3406 ni Imbaraga & Guhitamo SOS1 :: Inhibitor ya KRAS (IC50 = 5 nM), ifungura uburyo bushya bwo kuvura ibibyimba biterwa na KRAS. BI 3406 ihitamo guhuza SOS1 ikanahagarika imikoranire na KRAS, hatitawe ku ihinduka rya KRAS. BI 3406 itera RAS GTP na pERK igabanya kandi ikabuza gukura kwingirabuzimafatizo ya KRAS ihindagurika ryimikorere, itwara ibyinshi mubisanzwe byahinduwe na KRAS (ni ukuvuga G12D, G12V, G13D nibindi). BI 3406, iyo itanzwe kumunwa kumbeba zifite imbeba, itera ingaruka ziterwa nibibyimba bihamye bishobora guhinduka mugusubira inyuma iyo bihujwe na MEK1 kubuza.
Intego: SOS1
