SOS1

CAT #	Izina ryibicuruzwa	Ibisobanuro
CPD10000	BI-3406	BI-3406 ni Imbaraga & Guhitamo SOS1 :: Inhibitor ya KRAS (IC50 = 5 nM), ifungura uburyo bushya bwo kuvura ibibyimba biterwa na KRAS. BI 3406 ihitamo guhuza SOS1 ikanahagarika imikoranire na KRAS, hatitawe ku ihinduka rya KRAS. BI 3406 itera RAS GTP na pERK igabanya kandi ikabuza gukura kwingirabuzimafatizo ya KRAS ihindagurika ryimikorere, itwara ibyinshi mubisanzwe byahinduwe na KRAS (ni ukuvuga G12D, G12V, G13D nibindi). BI 3406, iyo itanzwe kumunwa kumbeba zifite imbeba, itera ingaruka ziterwa nibibyimba bihamye bishobora guhinduka mugusubira inyuma iyo bihujwe na MEK1 kubuza.
CPD2807	BAY-293	BAY-293 ninzitizi ikomeye ya SOS1 ibuza gukora RAS binyuze mu guhagarika imikoranire ya RAS-SOS1. BAY-293) ihitamo guhitamo imikoranire ya KRAS-SOS1 na IC50 ya 21 nM kandi ni iperereza ryimiti ryiperereza ryigihe kizaza.