BMS-986165

Izina ryimiti:

6- (cyclopropanecarboxamido) -4 - ( -carboxamide

Kode ya SMILES:

O = C (C1 = NN = C (NC (C2CC2) = O) C = C1NC3 = CC = CC (C4 = NN (C) C = N4) = C3OC) NC ([2H]) ([2H]) [ 2H]

InChi Code:

InChI = 1S / C20H22N8O3 / c1-21-20 (30) 16-14 (9-15 (25-26-16) 24-19 (29) 11-7-8-11) 23-13-6-4- 5-12 (17 (13) 31-3) 18-22-10-28 (2) 27-18 / h4-6,9-11H, 7-8H2,1-3H3, (H, 21,30) ( H2,23,24,25,29) / i1D3

InChi Urufunguzo:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Ijambo ryibanze:

1609392-27-9 ； CAS: 1609392-27-9 ； CAS ： 1609392-27-9 ； BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Gukemura:Gukemura muri DMSO

Ububiko:Kuma, umwijima no kuri 0 - 4 C mugihe gito (iminsi kugeza ibyumweru) cyangwa -20 C mugihe kirekire (amezi kugeza kumyaka).

Ibisobanuro:

BMS-986165 nimbaraga zikomeye kandi zatoranijwe za Allosteric Inhibitor ya TYK2. BMS-986165 Ifunga Il-12, IL-23 hanyuma wandike I Interferon Ikimenyetso kandi gitanga imbaraga zikomeye muburyo bwa Preclinical Models Indwara Zifata Indurwe. MS-986165 ihuza cyane na domeni ya Tyk2 pseudokinase (Ki = 0.02 nM), kandi ihitamo cyane kurwanya akanama ka 265 kinase na pseudokinase. Uru ruganda rwabujije cyane IL-23-, IL-12-, na Ubwoko I interferon-itwarwa na selile yerekana ibimenyetso hamwe nibisubizo byandikirwa (IC50 intera 2-14 nM).

Intego: TYK2