AZD8186

Izina ryimiti:

(R) -8- (1 - ((3.5

Kode ya SMILES:

O = C (N (C) C) C1 = CC ([C @@ H] (C) NC2 = CC (F) = CC (F) = C2) = C3C (C (C = C (O3) N4CCOCC4) = O) = C1

InChi Code:

InChI = 1S / C24H25F2N3O4 / c1-14 (27-18-11-16 (25) 10-17 (26) 12-18) 19-8-15 (24 (31) 28 (2) 3) 9-20- 21 (30) 13-22 (33-23 (19) 20) 29-4-6-32-7-5-29 / h8-14,27H, 4-7H2,1-3H3 / t14- / m1 / s1

InChi Urufunguzo:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Ijambo ryibanze:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

AZD8186 ni na inhibitor ya beta isoform ya fosifinositide-3 kinase (PI3K), hamwe nibikorwa bya antineoplastique. Ku buyobozi, PI3Kbeta inhibitor AZD8186 ihitamo guhitamo ibikorwa bya PI3Kbeta mumuhanda wa PI3K / Akt / mTOR, bishobora gutuma igabanuka ryikwirakwizwa rya selile. Itera kandi urupfu rw'uturemangingo muri selile ya kanseri ya PI3K. Mugushaka cyane cyane icyiciro I PI3K beta, iyi agent irashobora kuba nziza kandi idafite uburozi kuruta pan PI3K inhibitor. Ikimenyetso cya PI3K gikunze kugabanywa mu ngirabuzimafatizo za kanseri kandi kigira uruhare mu kongera imikurire y'uturemangingo, kubaho, no kurwanya ibibyimba ku miti itandukanye ya antineoplastique. AZD8186 kuri ubu iri mu cyiciro cya mbere cyamavuriro.

Intego: PI3K