Quizartinib; AC-010220; AC-220

Izina ryimiti:

N- (5-tert-Butylisoxazol-3-yl) -N '- {4- [7- (2-morpholin-4-ylethoxy) imidazo [2,1-b] fenil} urea

Kode ya SMILES:

O = C (NC1 = CC = C (C2 = CN3C (SC4 = CC (OCCN5CCOCC5) = CC = C34) = N2) C = C1) NC6 = NOC (C (C) (C) C) = C6

InChi Code:

InChI = 1S / C29H32N6O4S / c1-29 (2,3) 25-17-26 (33-39-25) 32-27 (36) 30-20-6-4-19 (5-7-20) 22- 18-35-23-9-8-21 (16-24 (23) 40-28 (35) 31-22) 38-15-12-34-10-13-37-14-11-34 / h4- 9,16-18H, 10-15H2,1-3H3, (H2,30,32,33,36)

InChi Urufunguzo:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Ijambo ryibanze:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi)

Ibisobanuro:

Quizartinib ni inhibitori ya FMS ifitanye isano na tyrosine kinase 3 (FLT3; Kd = 1,6 nM) kandi irerekana guhitamo kwinshi kuri FLT3 mugihe igeragezwa hamwe na 227 yinyongera ya kinase. Irabuza ikwirakwizwa ry'umurongo w'ingirabuzimafatizo ya muntu MV4-11, ibamo ihinduka ry’imiterere ya FLT3-ITD, ifite IC50 ifite agaciro ka 0.56 nM.1 Kuri 1 mg / kg / ku munsi, quizartinib yerekanwe ko ishobora kubaho mu mbeba. icyitegererezo cya FLT3-ITD acute myeloid leukemia no kurandura ibibyimba muburyo bwa FLT3 bushingiye ku mbeba xenograft yerekana 10 mg / kg.

Intego: FLT3