Tropifexor
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 800 |
| 1g | Zilipo | 1850 |
| 5g | Zilipo | 7400 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8- yl) -4-fluorobenzo[d]thiazole-6-carboxylic acid
SMILES Kodi:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4
InChi kodi:
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18(11-16)39-13-20-24( 35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14, 16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
InChi Key:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Mawu ofunika:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
Tropifexor (compound 1) ndi buku komanso agonist wamphamvu kwambiri wa FXR wokhala ndi EC50 ya 0.2 nM. Kulowetsedwa kwamphamvu kwa majini onse a BSEP ndi SHP kumawonedwa m'maselo oyamba ndi Tropifexor m'njira yodalira ndende. Kuwongolera kwa BSEP pamwamba pa galimoto (DMSO) kumayang'aniridwa pazigawo zotsika kwambiri monga 1 nM, pamene kulowetsedwa kwamphamvu kwa SHP (15-fold pamwamba pa galimoto) kumawonedwa pa 10 nM ndi kulowetsedwa pang'ono kwa SHP pa 1 nM (3-fold) [1 ].
Cholinga: FXR
