PCO371

Dzina la Chemical:

1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione

SMILES Kodi:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F)F )C=C4)N5)C5=O)=O)C(C)=C2)=O

InChi kodi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11 -13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30,31)32/h5-8,15-16H,9 -14H2,1-4H3,(H,33,35,39)(H,34,38,40)

InChi Key:

LTZJFVOUPUFOHX-UHFFFAOYSA-N

Mawu ofunika:

PCO371; PCO-371; Mtengo wa PCO371

Kusungunuka: 

Posungira: 

Kufotokozera:

PCO371 ndi agonist wamphamvu komanso wosankha wa PTHR1 pochiza hypoparathyroidism. Kuwongolera pakamwa kwa PCO371 kwa makoswe a osteopenic kumapangitsa kuti mafupa achuluke kwambiri komanso kuwonjezeka pang'ono kwa mafupa. Mu makoswe a hypocalcemic, PCO371 imabwezeretsanso kashiamu ya seramu popanda kuwonjezera kashiamu yamkodzo, komanso zotsatira zamphamvu komanso zokhalitsa kuposa jekeseni wa PTH.

Cholinga: PTHR1