Flibanserin

Dzina la Chemical:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

SMILES Kodi:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

InChi kodi:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Mawu ofunika:

Flibanserin, 167933-07-5

Kusungunuka:Zosungunuka mu DMSO

Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).

Kufotokozera:

Flibanserin ndi agonist wathunthu wa 5-HT1A receptor (Ki = 1 nM) ndipo, ndi chiyanjano chochepa, monga wotsutsa wa 5-HT2A receptor (Ki = 49 nM) ndi wotsutsa kapena wofooka kwambiri agonist wa D4 receptor ( Ki = 4–24 nM). Ngakhale kuti pali kugwirizana kwakukulu kwa flibanserin kwa 5-HT1A receptor, komanso pazifukwa zomwe sizikudziwika, flibanserin imakhala ndi 5-HT1A ndi 5-HT2A zolandilira mu vivo ndi magawo ofanana. Flibanserin imakhalanso ndi chiyanjano chochepa cha 5-HT2B receptor (Ki = 89.3 nM) ndi 5-HT2C receptor (Ki = 88.3 nM), zonse zomwe zimakhala ngati wotsutsa. Flibanserin amakonda kuyambitsa ma 5-HT1A receptors mu prefrontal cortex, kuwonetsa kusankhidwa kwa chigawo, ndipo apezeka kuti akuwonjezera dopamine ndi norepinephrine milingo ndikuchepetsa milingo ya serotonin mu rat prefrontal cortex, zochita zomwe zidatsimikiziridwa kuti zikhala pakati ndi kuyambitsa kwa 5-HT1A. cholandirira.[12] Mwakutero, flibanserin yafotokozedwa ngati norepinephrine-dopamine disinhibitor (NDDI). Flibanserin idavomerezedwa mu Ogasiti 2015 kuti azichiza azimayi omwe ali ndi vuto la chilakolako chogonana (HSDD).

Cholinga: 5HT