E-7046

Dzina la Chemical:

(S) -4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid

SMILES Kodi:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F)=O)C)C=C1

InChi kodi:

InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2 )20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32) ,33)/t11-/m0/s1

InChi Key:

MKLKAQMPKHNQPR-NSHDSACASA-N

Mawu ofunika:

E-7046, E7046, E 7046, 1369489-71-3

Kusungunuka:Zosungunuka mu DMSO

Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).

Kufotokozera:

Mu mtundu wa chotupa cha CT-26, kuphatikiza kwa E7046 / RT kumayambitsa kuyankha kwa anti-tumor kukumbukira kwa nyama 9. Muchitsanzo cha 4T1, kuphatikiza kwa E7046 ndi RT kumapanganso ntchito yoletsa kukula kwa chotupa poyerekeza ndi chithandizo chilichonse chokha. Kuphatikizikako kumathandizira kwambiri kupulumuka mwa kuletsa kusinthika kwapapo kwapapo kwa 4T1 [1]. E7046 (150 mg / kg) imalepheretsa kukula kwa mitundu ingapo ya chotupa cha syngeneic. Kutsekedwa kwa chizindikiro cha EP4 kumalimbikitsa kusiyanitsa kwa anti-tumor DC ndikuchepetsa kukula kwa chotupa mu mbewa. Chithandizo cha E7046 chimachepetsa kukula kapena kukanidwa zotupa zokhazikika mu vivo m'njira yodalira ma cell a myeloid ndi CD8C T. Kuphatikiza apo, kuphatikiza kwa E7046 ndi E7777, mapuloteni a IL-2-diphtheria toxin fusion omwe makamaka amapha Tregs, amasokoneza ma network a myeloid ndi Treg immunosuppressive, zomwe zimapangitsa kuti pakhale mayankho ogwira mtima komanso olimba a anti-tumor mumitundu ya chotupa cha mbewa [2] .

Zolinga: EP4