BI-3406
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 0.5g pa | Zilipo | 850 |
| 1g | Zilipo | 1450 |
| 5g | Zilipo | 6200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amine
SMILES Kodi:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2
InChi kodi:
InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11- 17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3,(H,28,29 ,30)/t12-,17+/m1/s1
InChi Key:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Mawu ofunika:
BI-3406; BI 3406; Mtengo wa BI3406
Kusungunuka:
Posungira:
Kufotokozera:
BI-3406 ndi Yamphamvu & Yosankha SOS1 :: KRAS Inhibitor (IC50=5 nM), Yomwe Imatsegula Njira Yatsopano Yochizira Zotupa Zoyendetsedwa ndi KRAS. BI 3406 mosankha imamangiriza ku SOS1 ndikuletsa kulumikizana ndi KRAS, mosasamala kanthu za kusintha kwa KRAS. BI 3406 imayambitsa kuchepa kwa RAS GTP ndi perK ndikulepheretsa kukula kwa maselo a KRAS osinthika ma cell, omwe amakhala ndi masinthidwe ambiri a KRAS (ie G12D, G12V, G13D ndi ena). BI 3406, ikaperekedwa pakamwa kwa chotupa chonyamula mbewa, imayambitsa mlingo wodalira chotupa chokhazikika chomwe chitha kusinthidwa kukhala ma regression akaphatikizidwa ndi chopinga cha MEK1.
Zolinga: SOS1
