BMS-986165
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 10 mg pa | Zilipo | 260 |
| 100 mg | Zilipo | 530 |
| 1g | Zilipo | 1350 |
Dzina la Chemical:
6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 - carboxamide
SMILES Kodi:
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]
InChi kodi:
InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3
InChi Key:
BZZKEPGENYLQSC-FIBGUPNXSA-N
Mawu ofunika:
1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9;BMS-986165; BMS 986165; BMS986165; Deucravacitinib
Kusungunuka:Zosungunuka mu DMSO
Posungira:Zouma, zakuda ndi 0 - 4 C kwa nthawi yochepa (masiku mpaka masabata) kapena -20 C kwa nthawi yaitali (miyezi mpaka zaka).
Kufotokozera:
BMS-986165 ndi Yamphamvu Kwambiri komanso Yosankha Allosteric Inhibitor ya TYK2. BMS-986165 Blocks Il-12, IL-23 ndi mtundu I Interferon Signaling ndipo Amapereka Mphamvu Yamphamvu mu Preclinical Models of Inflammatory Bowel Disease. MS-986165 imamangiriza mwamphamvu ku domain ya Tyk2 pseudokinase (Ki = 0.02 nM), ndipo imasankha kwambiri gulu la 265 kinases ndi pseudokinases. Pulogalamuyi idalepheretsa IL-23-, IL-12-, ndi Type I interferon-driven cellular signing and transcriptional responses (IC50 range 2-14 nM).
Cholinga: TYK2
