SOS1

MPAKA #	Dzina lazogulitsa	Kufotokozera
CPD10000	BI-3406	BI-3406 ndi Yamphamvu & Yosankha SOS1 :: KRAS Inhibitor (IC50=5 nM), Yomwe Imatsegula Njira Yatsopano Yochizira Zotupa Zoyendetsedwa ndi KRAS. BI 3406 mosankha imamangiriza ku SOS1 ndikuletsa kulumikizana ndi KRAS, mosasamala kanthu za kusintha kwa KRAS. BI 3406 imayambitsa kuchepa kwa RAS GTP ndi perK ndikulepheretsa kukula kwa maselo a KRAS osinthika ma cell, omwe amakhala ndi masinthidwe ambiri a KRAS (ie G12D, G12V, G13D ndi ena). BI 3406, ikaperekedwa pakamwa kwa chotupa chonyamula mbewa, imayambitsa mlingo wodalira chotupa chokhazikika chomwe chitha kusinthidwa kukhala ma regression akaphatikizidwa ndi chopinga cha MEK1.
CPD2807	BAY-293	BAY-293 ndi choletsa champhamvu cha SOS1 chomwe chimalepheretsa kuyambitsa kwa RAS kudzera kusokoneza kuyanjana kwa RAS-SOS1. BAY-293) mosankha amaletsa kuyanjana kwa KRAS-SOS1 ndi IC50 ya 21 nM ndipo ndi kafukufuku wofunikira wamankhwala ofufuza zamtsogolo.