SB-204990

Ingoa matū:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Waehere SMILES:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Waehere InChi:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21) 22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Kī InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Kupumatua:

SB-204990, SB 204990, SB204990

Wairewa: 

Rokiroki: 

Whakaahuatanga:

SB-204990 Ko te prodrug o te kaha ATP citrate-lyase inhibitor SB-201076. Ko te SB-204990, ka tukuna-waha ki te kiore, ka uru ki roto i te tohanga o te punaha, ka whakahokia mai nga kohinga rongoa o SB-201076 i roto i te ate. Ko te SB-204990 (25 mg/kg ia ra) i heke iho nga taumata cholesterol plasma (tae atu ki te 23%) me nga taumata triglyceride (tae atu ki te 38%) i roto i te kuri, he pai ake te whakaheke i te lipoprotein iti-kiato ka whakaritea ki te cholesterol lipoprotein teitei. taumata. Ko te SB-204990 he whākōkī nui i roto i te whakahaere i te tuku tïpako mo te whakahiato lipid de novo me te whäinga enakia mo te wawaotanga hypolipidaemic.

Whāinga: