| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD3611 | SB-204990 | SB-204990 Ko te prodrug o te kaha ATP citrate-lyase inhibitor SB-201076. Ko te SB-204990, ka tukuna-waha ki te kiore, ka uru ki roto i te tohanga o te punaha, ka whakahokia mai nga kohinga rongoa o SB-201076 i roto i te ate. Ko te SB-204990 (25 mg/kg ia ra) i heke iho nga taumata cholesterol plasma (tae atu ki te 23%) me nga taumata triglyceride (tae atu ki te 38%) i roto i te kuri, he pai ake te whakaheke i te lipoprotein iti-kiato ka whakaritea ki te cholesterol lipoprotein teitei. taumata. Ko te SB-204990 he whākōkī nui i roto i te whakahaere i te tuku tïpako mo te whakahiato lipid de novo me te whäinga enakia mo te wawaotanga hypolipidaemic. |
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