Luxdegalutamide; ARV-766

Luxdegalutamide; ARV-766
  • Ingoa:4-(4-((1-(4-(((1r,3r))-3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperidin-4- yl)methyl)piperazin-1-yl)-N-((S)-2,6-dioxopiperidin-3-yl)-2-fluorobenzamide
  • Nama Putumōhio:CPD115335
  • Nama CAS:2750830-09-0
  • Taumaha rāpoi:807.95
  • Tātai matū:C45 H54 F N7 O6
  • Mo nga rangahau pūtaiao anake, kaua mo nga turoro.

    Taipitopito Hua

    Tohu Hua

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    Ingoa matū:

    4-(4-((1-(4-(((1r,3r))-3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperidin-4- yl)methyl)piperazin-1-yl)-N-((S)-2,6-dioxopiperidin-3-yl)-2-fluorobenzamide

    Waehere SMILES:

    CC1(C)[C@H](NC(C2=CC=C(N3CCC(CN4CCN(C5=CC(F))=C(C(N[C@@H]6C(=O)NC(=O)) CC6)=O)C=C5)CC4)CC3)C=C2)=O)C(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

    Waehere InChi:

    InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50- 39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32- 11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28,36, 42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0/s1

    Kī InChi:

    RDPPBRKNBBXPNZ-FMPIRMQTSA-N

    Kupumatua:

    2750830-09-0;CAS:2750830-09-0;CAS:2750830-09-0;ARV766; ARV 766; ARV-766; GTPL12624; luxdegalutamide

    Wairewa: 

    Rokiroki:He maroke, he pouri me te 0 - 4 C mo te wa poto (ra ki nga wiki) ranei -20 C mo te wa roa (marama ki nga tau).

    Whakaahuatanga:

    Ko te Luxdegalutamide (ARV-766) he huanga-a-waha e whai hua ana ki te hydrolysis pūmua chimeric (PROTAC) e aro ana ki te kaiwhakawhiwhi androgen (AR), ka taea te whakaheke i nga mutants e pa ana ki te AR.

    Whāinga: AR




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