BMS-986165

Ingoa matū:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 -carboxamide

Waehere SMILES:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

Waehere InChi:

InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12(17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3

Kī InChi:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Kupumatua:

1609392-27-9；CAS:1609392-27-9；CAS:1609392-27-9；BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Wairewa:Wairewa i roto i te DMSO

Rokiroki:He maroke, he pouri me te 0 - 4 C mo te wa poto (ra ki nga wiki) ranei -20 C mo te wa roa (marama ki nga tau).

Whakaahuatanga:

Ko te BMS-986165 he Kaipupuri Allosteric tino kaha me te whiriwhiri o TYK2. BMS-986165 Poraka Il-12, IL-23 me te momo I Interferon Signaling me te whakarato mo te kaha pakari i roto i nga tauira o mua o te mate pukupuku o te mate pukupuku. He kaha te here a MS-986165 ki te rohe Tyk2 pseudokinase (Ki = 0.02 nM), a he tino whiriwhiri ki te roopu o 265 kinases me pseudokinases. Ko te pūhui i kaha te aukati i te IL-23-, IL-12-, me te Momo I interferon-driven cell signaling and transcriptional responses (IC50 range 2-14 nM).

Whāinga: TYK2