BI-3406

Ingoa matū:

N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amine

Waehere SMILES:

C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2

Waehere InChi:

InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11-17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29,30)/t12-,17+/m1/s1

Kī InChi:

XVFDNRYZXDTHHT-PXAZEXFGSA-N

Kupumatua:

BI-3406; BI 3406; BI3406

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te BI-3406 he SOS1 Potent & Selective::KRAS Inhibitor (IC50=5 nM), e Whakatuwhera ana i te huarahi hou mo te maimoatanga i nga pukupuku a-KRAS. Ko te BI 3406 ka herea ki te SOS1 me te aukati i te taunekeneke me te KRAS, ahakoa te rereke o te KRAS. Ko te BI 3406 ka whakaheke i te RAS GTP me te pERK me te aukati i te tipu o nga pūtau o nga raina pūtau kua whakarereketia a KRAS, e mau ana i te nuinga o nga huringa KRAS angamaheni (ara G12D, G12V, G13D me etahi atu). Ko te BI 3406, ka tukuna-waha ki nga kiore e mau ana i te puku, ka puta he paanga pateko o te puku e whakawhirinaki ana ki te horopeta ka taea te huri ki te hurihanga ina honoa me te aukati MEK1

Whāinga: SOS1