Sildenafil Citrate

Nomen chemicum:

5-(2-ethoxy-5-((4-methylpiperazin-1-yl) sulfonyl) phenyl) -1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin- 7-unum 2-hydroxypropane-1,2,3-tricarboxylatum

SMILES Code:

"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(C(O)O)(C(=O)O)O "

InChi Code:

InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10- 26(3)11-13-28; 7-3(8) 1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2; 1-4H3(H,23,24,29);

InChi Key:

DEIYFTQMQPDXOT-UHFFFAOYSA-N

Keyword:

Sildenafil Citrate；UK 92480-10；UK-92,480-10； Revatio； VIAGRA171599-83-0；CAS:171599-83-0；CAS：171599-83-0

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

Sildenafil, Citrate est forma citrata Sildenafil. Sildenafil est inhibitor selectivus PDE5 (type 5 cGMP phosphodiesterasis) quae catalysin hydrolyseos 3',5'-cyclicae monophosphatis guanosini (cGMP). Sicut inhibitor PDE5, Sildenafil relatum est ad augendae neuro-, synapto- et angiogenesis in rat exemplaribus ictuum et praeterea vasodilator lenis esse traditur. Sildenafil etiam ostensum est ad indomethacin-actionem parvam ulcerationem intestinorum per NO/cGMP- mechanismum dependens.

Target: PDE5