OTS964

Nomen chemicum:

(R) -9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

SMILES Code:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC = C4

InChi Code:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H 24,27); /m0./s1

InChi Key:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Keyword:

OTS 964, OTS-964, OTS964, 1338545-07-5

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

OTS964 est inhibitor interfectoris lymphokini-activi T cellulae interdum kinasi natae (TOPK; IC50 = 28 nM). Praecipue impedit cytokinesim, apoptosin ducens, in latitudine cellularum cancri. OTS964 apoptosim inducit cellulas cancri pulmonis humani in xenografts mus.

Target: TOPK