GDC-0326

Nomen chemicum:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

SMILES Code:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

InChi Code:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-166-8-13(28-12(3)17( 20) 4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

InChi Key:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Keyword:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solubilitas:Solutum in DMSO

Repono:0 - 4° C pro brevi termino (dies ad hebdomades), vel -20° C ad terminum longum (menses)

Descriptio:

GDC-0326 vehemens et selectivus inhibitor of α-Isoformia Phosphoinositidis 3-Kinase (PI3Kalpha inhibitor). GDC-0326 altiorem gradum selectivity consequitur in alias kinases. GDC-0326 humilis plasma CL in humano habet. Intra kinasem PI3 familiam, PI3K isoformes I quatuor sunt (α, β, δ, et γ). Harum isoformium, PI3Kα maxime cum carcinomatis coniungitur.

Target: PI3K