IACS-010759

IACS-010759
  • Nomen:IACS-010759
  • Catalogue No.CPDB1805
  • CAS No.:1570496-34-2 (basi gratis) 1807523-99-4 (HCl)
  • Pondus hypotheticum:562.568
  • Formulae chemica:C25H25F3N6O4S
  • Investigationes scientificae tantum, non aegros.

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    Nomen chemicum:

    5-(5-methyl-1-(3-(4. phenyl) 1,2,4-oxadiazole

    SMILES Code:

    FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(O))(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

    InChi Code:

    InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14; 21H,10-13,15H2,1-2H3

    InChi Key:

    HWJWNWZJUYCGKV-UHFFFAOYSA-N

    Keyword:

    IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

    Solubilitas:Solutum in DMSO

    Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).

    Descriptio:

    IACS-01759 vel IACS-10759 inhibitor est potens et selectivus oxidative Phosphorylation (IC50<10 nM) cum actione antineoplastica potentiali. IACS-010759 ligat et inhibet complexum I catenae onerariae electronicae (NADH ubiquinone oxidoreductase), eo quod selective privat tumorem cellularum nutrimentorum, et industriam et productionem acidum nucleotide et amino inhibito, quae autophagiam inducit, mortem efficit tumorem et cellulam vetat. multiplicatio. Mitochondriale complexum I, quod hyperactivated in cellulis canceris obviam auctae industriae postulatis suis, munus agit praecipuum in prolificatione cellae cancri promovendae.

    Scopum: OXPHOS


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