BAV-850

Nomen chemicum:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

SMILES Code:

ClC(C(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

InChi Code:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28 (11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(. 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H. ,44,45)/t25-,29-,30+,31-/m1/s1

InChi Key:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Keyword:

BAV 850; BAY850; BAV 850

Solubilitas:DMSO

Repono: 

Descriptio:

"BY-850 specillum chemicum pro bromodomain ATAD2A quod acetyllatum H4 peptidium ab ATAD2 bromodomain ponit cum valore IC50 20 nM (HTRF). 850 exquisitam selectivam prae omnibus aliis bromodomainis ostendit (nulla hit in BROMOscan ad 10 µM) ac plenam longitudinem ATAD2 ex chromatin in cellulis vivis ad collationem 1 µM iuxta FRAP definit 5 µM non commendantur.

Scopum: chemica specillum pro ATAD2A bromodomain