STING agonîst-4

Navê Kîmyayî:

1,1'-(butane-1,4-diyl)bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)

Koda SMILES:

O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC) (C)=NN6CC)=O)=NC2=C1)N

Koda InChi:

InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23- 17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)4 8) 18-24 (26) 38-34 (44) 40-32 (50) 28-16-20 (4) 42-46 (28) 6-2 / h9-12,15-18 H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50)

Bişkojka InChi:

ICZSAXDKFXTSGL-UHFFFAOYSA-N

Keyword:

Çareserî: 

Embarkirinî: 

Terîf:

STING agonist-4 stimulatorê agonîstê receptorê Genên Interferon (STING) ye ku bi berdewamiya înhibitor a diyar (IC50) 20 nM ye. STING agonist-4 pêkhateyek du simetrî-girêdayî amidobenzimidazole (ABZI) ye ku ABZI-yên girêdayî (diABZIs) bi girêdana zêdekirî ya bi STING û fonksiyona hucreyî re diafirîne.

Armanc: STING