STING agonîst-3

STING agonîst-3
  • Nav:STING agonîst-3
  • Hejmara Katalogê:CPD101231
  • Hejmara CAS:2138299-29-1
  • Giraniya molekulî:750.8
  • Formula Kîmyewî:C37 H42 N12 O6
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    Mezinahiya pakêtê Berdestbûnî Biha (USD)

    Navê Kîmyayî:

    (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazol-1-yl)but-2- en-1- yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazole-5-carboxamide

    Koda SMILES:

    O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC) (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1

    Koda InChi:

    InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(3 2 (38) 51) 10-11-27 (25) 46 (36) 12-7-8-13-47-31-26 (19-24 (33 (39) 52) 20-30 (31) 55- 15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20, 50 H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8 -7+

    Bişkojka InChi:

    VHCDRDBBENBVEK-BQYQJAHWSA-N

    Keyword:

    Çareserî: 

    Embarkirinî: 

    Terîf:

    STING agonîst-3, ku ji patenta WO2017175147A1 (mînak 10) hatî derxistin, agonîstek STING ya molekulek piçûk a hilbijartî û ne-nukleotidî ye ku bi pEC50 û pIC50 bi rêzdarî 7,5 û 9,5 e. STING agonist-3 xwedan bandorek antî-tumor a domdar û potansiyelek mezin e ku dermankirina penceşêrê baştir bike

    Armanc: STING


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