Quizartinib; AC-010220; AC-220

Jeneng Kimia:

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yletoxy)imidazo[2,1-b][1,3]benzotiazol-2-yl ]fenil}urea

Kode SMILES:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6

Kode Inchi:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

Kunci InChi:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

tembung kunci:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Kelarutan:Larut ing DMSO

Panyimpenan:0 - 4°C kanggo jangka cendhak (dina nganti minggu), utawa -20°C kanggo jangka panjang (sasi)

katrangan:

Quizartinib minangka inhibitor tirosin kinase 3 sing gegandhengan karo FMS (FLT3; Kd = 1.6 nM) lan nduduhake selektivitas dhuwur kanggo FLT3 nalika dites karo panel 227 kinase tambahan. Nyandhet proliferasi garis sel leukemia manungsa MV4-11, sing nduweni mutasi FLT3-ITD homozigot, kanthi nilai IC50 0,56 nM.1 Ing 1 mg / kg / dina, quizartinib wis ditampilake kanggo ngluwihi kaslametan ing mouse. model leukemia myeloid akut FLT3-ITD lan kanggo mbasmi tumor ing model xenograft mouse gumantung FLT3 ing 10 mg / kg.

Sasaran: FLT3