BLU-667

Jeneng Kimia:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pirazol-1-yl)fenil)etil)-1-metoxy-4-(4-metil-6-( (5-metil-1H-pirazol-3-yl)amino)pirimidin-2-yl)sikloheksana-1-karboxamide

Kode SMILES:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

Kode Inchi:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21)27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

Kunci InChi:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

tembung kunci:

BLU-667; BLU 667; BLU667

Kelarutan:DMSO

Panyimpenan: 

katrangan:

BLU-667 minangka inhibitor kuat lan selektif mutasi RET, fusi, lan mutan tahan sing diprediksi. Fusi RET minangka panyebab utama kanker, kalebu kanker paru-paru lan tiroid, lan riset kita nuduhake yen RET uga nduweni peran penting ing sawetara kanker usus besar lan payudara. Kanthi nargetake driver utami lan mutan tahan sing diprediksi sing nyebabake sel kanker ora sensitif kanggo perawatan karo obat sing saiki disetujoni,

Sasaran: RET