BAY-299

Jeneng Kimia:

2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3( 2H)-dione

Kode SMILES:

OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O

Kode Inchi:

InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8- 4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6, 11H2,1-3H3

Kunci InChi:

OFWWWKWUCDUISA-UHFFFAOYSA-N

tembung kunci:

BAY-299, BAY 299, BAY299, 2080306-23-4

Kelarutan:Larut ing DMSO

Panyimpenan:0 - 4°C kanggo jangka cendhak (dina nganti minggu), utawa -20°C kanggo jangka panjang (sasi).

katrangan:

BAY-299 minangka inhibitor kuat lan selektif saka bromodomain lan PHD sing ngemot driji (BRPF) protein kulawarga BRD1 (IC50 = 6 nM), uga dikenal minangka BRPF2, lan bromodomain kaloro saka faktor inisiasi transkripsi subunit TFIID 1 (TAF1; IC50). = 13 nM).1 BAY-299 luwih selektif 30 kali tinimbang BRPF1, BRPF3, BRD9, lan ATAD2 lan luwih saka 300 kali selektif tinimbang BRD4.

Sasaran: BRPF