PRT-060318; PRT318; P142–76

Aha kemịkalụ:

2-((1R,2S) -2-aminocyclohexyl) amino) -4- (m-tolylamino) pyrimidine-5-carboxamide

Koodu Ọchịchọ:

O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

Koodu InChi:

InChi=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24)/t14-,15+/m0/s1

Igodo InChi:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

Okwu:

PRT-060318, PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

PRT060318 bụ onye na-eme ihe ike ma na-ahọrọ nke spleen tyrosine kinase (Syk; IC50 = 4 nM) .Ọ bụ nhọrọ, na-egbochi 92% nke ọrụ Syk, ebe ndị ọzọ kinases na-ejigide>70% ọrụ, na ntinye nke 50 nM na panel panel nke. 270 ụdị. PRT060318 na-egbochi mkpọkọ na-akpata convulxin nke plasma-bara ọgaranya mmadụ (IC50 = 2.5 μM) na vitro ma gbochie thrombosis n'ụdị òké transgenic nke heparin na-ebute thrombocytopenia. Ọ na-ebute ọrịa leukemia lymphocytic na-adịghị ala ala (CLL) B cell apoptosis ma na-egbochi nzuzo nke chemokines CCL3, CCL4, na CXCL13.3 PRT060318 na-egbochikwa CLL B cell chemotaxis na pseudoemperipolesis.

Ebumnuche: Syk