BAY 61-3606 2HCl

Aha kemịkalụ:

2-[7- (3,4-Dimethoxyphenyl) imidazo [1,2-c] pyrimidin-5-yl] amino] -3-pyridinecarboxamide dihydrochloride.

Koodu Ọchịchọ:

O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

Koodu InChi:

InChi=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20 (24-14)25-19-13 (18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24) ,25);2*1H

Igodo InChi:

SPMFEULFGGPQLN-UHFFFAOYSA-N

Okwu:

BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

BAY 61-3606 bụ onye nwere ike (Ki = 7.5 nM) yana onye na-egbochi Syk kinase. BAY 61-3606 gbochiri ọ bụghị naanị mbibi (ụkpụrụ IC50 n'etiti 5 na 46 nM) kamakwa onye ogbugbo lipid na njikọ cytokine na sel mast. BAY 61-3606 dị irè nke ukwuu na basophils enwetara site na ndị mmadụ nwere ahụike (IC50 = 10 nM) ma yie ka ọ dịkarịa ala dị ka ike na basophils nwetara site na atopic (high serum IgE) isiokwu (IC50 = 8.1 nM). BAY 61-3606 na-egbochi nnabata nke cell B cell na ndị na-anabata maka akụkụ Fc nke akara IgG na eosinophils na monocytes.

Ebumnuche: Syk