GDC-0326

Aha kemịkalụ:

(S)-2-(2- (1-isopropyl-1H-1,2,4-triazol-5-yl) -5,6-dihydrobenzo [f] imidazo [1,2-d] [1,4] ]oxazepin-9-yl) oxy) propanamide

Koodu Ọchịchọ:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Koodu InChi:

InChi=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3) )17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/ m0/s1

Igodo InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Okwu:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

Nkọwa:

GDC-0326 bụ onye na-egbochi ike na nhọrọ nke α-Isoform nke Phosphoinotide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 na-enweta ọkwa dị elu nke nhọrọ nhọrọ karịa kinase ndị ọzọ. GDC-0326 nwere obere plasma CL na mmadụ. N'ime ezinụlọ PI3 kinase, enwere klaasị anọ I PI3K isoforms (α, β, δ, na γ). N'ime isoforms ndị a, PI3KA bụ nke a na-ejikọtakarị na ọrịa cancer.

Ebumnuche: PI3K