BAY-299

Aha kemịkalụ:

2- (2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimizol-5-yl) -6- (3-hydroxypropyl) -1H-benz [de] isoquinoline-1,3 ( 2H - dione

Koodu Ọchịchọ:

OCCCC1=CC=C(C(N2C3=C(C)C=C(N(C)C(N4C)=O)C4=C3=O)C5=C1C=CC=C5C2=O

Koodu InChi:

InChi=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7- 16-15 (6-5-11-29)9-10-18 (22 (16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1- 3H3

Igodo InChi:

OFWWWKWUCDUISA-UHFFFAOYSA-N

Okwu:

BAY-299, BAY 299, BAY299, 2080306-23-4

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

BAY-299 bụ onye na-egbochi ike ma na-ahọrọ nke bromodomain na PHD mkpịsị aka nwere (BRPF) protein ezinụlọ BRD1 (IC50 = 6 nM), nke a makwaara dị ka BRPF2, na bromodomain nke abụọ nke ntinye mmalite TFIID subnits 1 (TAF1; IC50). = 13 nM).1 BAY-299 bụ> 30-fold ahọpụtara n'elu BRPF1, BRPF3, BRD9, na ATAD2 na bụ>300-fold ahọpụtara n'elu BRD4.

Ebumnuche: BRPF