BI-3406

Aha kemịkalụ:

N ((R) -1- (3-amino-5- (trifluoromethyl) phenyl) ethyl) -7-methoxy-2-methyl-6- (((S) -tetrahydrofuran-3-yl) oxy) quinazolin- 4-amine

Koodu Ọchịchọ:

C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 =NC(C)=N2

Koodu InChi:

InChi=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11- 17)20 (31-3) 10-19 (18)29-13 (2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3, (H,28,29 ,30)/t12-,17+/m1/s1

Igodo InChi:

XVFDNRYZXDHTHT-PXAZEXFGSA-N

Okwu:

BI-3406; BI 3406; BI3406

Solubility: 

Nchekwa: 

Nkọwa:

BI-3406 nwere ike & Nhọrọ SOS1 :: KRAS Inhibitor (IC50=5 nM), nke na-emepe Ụzọ Ọhụrụ maka ọgwụgwọ Tumours-KRAS. BI 3406 na-ahọrọ nke ọma na SOS1 ma gbochie mmekọrịta ya na KRAS, n'agbanyeghị ngbanwe KRAS. BI 3406 na-ebute mbelata RAS GTP na PERK ma na-egbochi uto cell nke ahịrị cell mutated KRAS, na-ebu ọtụtụ ngbanwe nke KRAS (ya bụ G12D, G12V, G13D na ndị ọzọ). BI 3406, mgbe a na-enye ya ọnụ na oke ndị na-ebu etuto ahụ, na-ebute nsonaazụ dabere tumor static mmetụta nke enwere ike ịtụgharị ka ọ bụrụ nkwụghachi azụ mgbe ejikọtara ya na mgbochi MEK1.

Ebumnuche: SOS1