SOS1

nwamba #	Aha ngwaahịa	Nkọwa
CPD10000	BI-3406	BI-3406 nwere ike & Nhọrọ SOS1 :: KRAS Inhibitor (IC50=5 nM), nke na-emepe Ụzọ Ọhụrụ maka ọgwụgwọ Tumours-KRAS. BI 3406 na-ahọrọ nke ọma na SOS1 ma gbochie mmekọrịta ya na KRAS, n'agbanyeghị ngbanwe KRAS. BI 3406 na-ebute mbelata RAS GTP na PERK ma na-egbochi uto cell nke ahịrị cell mutated KRAS, na-ebu ọtụtụ ngbanwe nke KRAS (ya bụ G12D, G12V, G13D na ndị ọzọ). BI 3406, mgbe a na-enye ya ọnụ na oke ndị na-ebu etuto ahụ, na-ebute nsonaazụ dabere tumor static mmetụta nke enwere ike ịtụgharị ka ọ bụrụ nkwụghachi azụ mgbe ejikọtara ya na mgbochi MEK1.
CPD2807	BAY-293	BAY-293 bụ ihe mgbochi SOS1 siri ike nke na-egbochi ịgbalite RAS site na imebi mmekọrịta RAS-SOS1. BAY-293) na-akpachapụ anya na-egbochi mmekọrịta KRAS-SOS1 na IC50 nke 21 nM ma bụrụ nyocha kemịkalụ bara uru maka nyocha n'ọdịnihu.