BMS-986165

Aha kemịkalụ:

6- (cyclopropanecarboxamido) -4 ((2-methoxy-3- (1-methyl-1H-1,2,4-triazol-3-yl) phenyl) amino) - N- (methyl-d3) pyridazine-3 - Carboxamide

Koodu Ọchịchọ:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4=C3OC)NC([2H])([2H])[ 2H]

Koodu InChi:

InChi=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17 (13) 31-3) 18-22-10-28 (2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)( H2,23,24,25,29)/i1D3

Igodo InChi:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Okwu:

1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9：BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Solubility:Soluble na DMSO

Nchekwa:Akọrọ, ọchịchịrị na na 0 - 4 C maka obere oge (ụbọchị ruo izu) ma ọ bụ -20 C maka ogologo oge (ọnwa ruo afọ).

Nkọwa:

BMS-986165 bụ onye nwere ike dị ukwuu na onye na-eme ihe mgbochi allosteric nke TYK2. BMS-986165 Ihe mgbochi Il-12, IL-23 na ụdị I Interferon Signaling ma na-enye maka arụmọrụ siri ike na ụdị nke mbụ nke ọrịa afọ na-efe efe. MS-986165 na-ejikọ ike na ngalaba Tyk2 pseudokinase (Ki = 0.02 nM), ma na-ahọrọ nke ukwuu megide otu panel nke 265 kinases na pseudokinases. Ngwakọta ahụ jisiri ike gbochie IL-23-, IL-12-, na Ụdị I interferon na-ebute ihe nrịbama cell na nzaghachi ederede (IC50 nso 2-14 nM).

Ebumnuche: TYK2