AZD8186

AZD8186
  • Aha:AZD8186
  • Nọmba katalọgụ:CPDB0202
  • Nọmba CAS:1627494-13-6
  • Arọ Molecular:457.4
  • Usoro kemịkalụ:C24H25F2N3O4
  • Maka nyocha sayensị naanị, ọ bụghị maka ndị ọrịa.

    Nkọwa ngwaahịa

    Mkpado ngwaahịa

    Nha ngwugwu Nnweta Ọnụ ego (USD)
    100mg Dị na ngwaahịa 350
    500mg Dị na ngwaahịa 700
    Nha ndị ọzọ Nweta Quotes Nweta Quotes

    Aha kemịkalụ:

    (R) -8- (1- ((3,5-difluorophenyl) amino) ethyl) -N, N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

    Koodu Ọchịchọ:

    O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

    Koodu InChi:

    InChi=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1

    Igodo InChi:

    LMJFJIDLEAWOQJ-CQSZACIVSA-N

    Okwu:

    AZD8186, AZD-8186, AZD 8186, 1627494-13-6

    Solubility:Soluble na DMSO

    Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)

    Nkọwa:

    AZD8186 bụ na onye na-egbochi beta isoform nke phosphoinotide-3 kinase (PI3K), nwere ọrụ antineoplastic nwere ike. Mgbe nchịkwa, PI3Kbeta inhibitor AZD8186 na-ahọrọ nke ọma na-egbochi ọrụ PI3Kbeta na ụzọ akara PI3K/Akt/mTOR, nke nwere ike ịkpata mbelata nke mmụba cell tumor. Ọ na-ebutekwa ọnwụ cell na PI3K na-egosipụta mkpụrụ ndụ kansa. Site n'ichebe klaasị I PI3K beta kpọmkwem, onye nnọchi anya a nwere ike ịdị na-arụ ọrụ nke ọma yana obere egbu egbu karịa pan PI3K inhibitors. Mgbama mgbasa ozi PI3K na-enwekarị dysregulated na mkpụrụ ndụ kansa ma na-enye aka n'ịbawanye uto cell tumor, nlanarị, na mgbochi tumor n'ọtụtụ ọgwụ antineoplastic. AZD8186 nọ ugbu a n'okpuru ule ụlọ ọgwụ nke Oge I.

    Ebumnuche: PI3K


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