AZD8186
Nkọwa ngwaahịa
Mkpado ngwaahịa
Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
100mg | Dị na ngwaahịa | 350 |
500mg | Dị na ngwaahịa | 700 |
Nha ndị ọzọ | Nweta Quotes | Nweta Quotes |
Aha kemịkalụ:
(R) -8- (1- ((3,5-difluorophenyl) amino) ethyl) -N, N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide
Koodu Ọchịchọ:
O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1
Koodu InChi:
InChi=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1
Igodo InChi:
LMJFJIDLEAWOQJ-CQSZACIVSA-N
Okwu:
AZD8186, AZD-8186, AZD 8186, 1627494-13-6
Solubility:Soluble na DMSO
Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa)
Nkọwa:
AZD8186 bụ na onye na-egbochi beta isoform nke phosphoinotide-3 kinase (PI3K), nwere ọrụ antineoplastic nwere ike. Mgbe nchịkwa, PI3Kbeta inhibitor AZD8186 na-ahọrọ nke ọma na-egbochi ọrụ PI3Kbeta na ụzọ akara PI3K/Akt/mTOR, nke nwere ike ịkpata mbelata nke mmụba cell tumor. Ọ na-ebutekwa ọnwụ cell na PI3K na-egosipụta mkpụrụ ndụ kansa. Site n'ichebe klaasị I PI3K beta kpọmkwem, onye nnọchi anya a nwere ike ịdị na-arụ ọrụ nke ọma yana obere egbu egbu karịa pan PI3K inhibitors. Mgbama mgbasa ozi PI3K na-enwekarị dysregulated na mkpụrụ ndụ kansa ma na-enye aka n'ịbawanye uto cell tumor, nlanarị, na mgbochi tumor n'ọtụtụ ọgwụ antineoplastic. AZD8186 nọ ugbu a n'okpuru ule ụlọ ọgwụ nke Oge I.
Ebumnuche: PI3K