Tropifexor
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 100 mg | Nan stock | 800 |
| 1g | Nan stock | 1850 |
| 5g | Nan stock | 7400 |
| Plis gwosè | Jwenn Quotes | Jwenn Quotes |
Non Chimik:
2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)izoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8- yl) -4-fluorobenzo [d] thiazole-6-carboxylic asid
Kòd SMILES:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4
Kòd InChi:
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31, 32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
InChi kle:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Mot:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).
Deskripsyon:
Tropifexor (konpoze 1) se yon agonist roman ak trè pisan nan FXR ak yon EC50 nan 0.2 nM. Tropifexor obsève endiksyon solid nan tou de jèn BSEP ak SHP nan selil prensipal yo nan yon fason ki depann de konsantrasyon. Yo obsève kontwòl BSEP endiksyon pi wo pase machin (DMSO) nan konsantrasyon osi ba ke 1 nM, pandan y ap endiksyon fò nan SHP (15-pliye pi wo a veyikil) obsève nan 10 nM ak modès endiksyon SHP nan 1 nM (3-pliye)[1 ].
Sib: FXR
