Ertugliflozin

Non Chimik:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]oktan-2,3 ,4-triol

Kòd SMILES:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(C(O3)(CO4)CO)O)O)O)Cl"

Kòd InChi:

"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27) )18(25)19(2 6)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+ ,21-,22-/m0/s1 "

InChi kle:

"MCIACXAZCBVDEE-CUUWFGFTSA-N"

Mot:

Ertugliflozin, PF 04971729,MK-8835,1210344-57-2

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).

Deskripsyon:

Ertugliflozin, ke yo rele tou PF-04971729, se yon inibitè ki pisan ak selektif nan cotransporter glikoz sodyòm-depandan 2 ak kandida klinik pou tretman dyabèt tip 2. etid klinik te montre ke Ertugliflozin (1-25 mg / jou) amelyore kontwòl glisemi, pwa kò ak san presyon nan pasyan ki gen T2DM pa pi bon kontwole sou metformin, e li te byen tolere.

Sib: SGLT-2