IACS-010759
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 100 mg | Nan Stock | 300 |
| 500 mg | Nan Stock | 800 |
| 1g | Nan Stock | 1200 |
| Plis gwosè | Jwenn Quotes | Jwenn Quotes |
Non Chimik:
5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) fenil)-1,2,4-oksadiazol
Kòd SMILES:
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1
Kòd InChi:
InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3
InChi kle:
HWJWNWZJUYCGKV-UHFFFAOYSA-N
Mot:
IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).
Deskripsyon:
IACS-010759 oswa IACS-10759 se yon inibitè fosforilasyon oksidatif ki pisan ak selektif (IC50).< 10 nM) ak potansyèl aktivite antineoplastic. IACS-010759 mare ak inibit konplèks I nan chèn transpò elèktron (NADH ubiquinone oxidoreductase), kidonk oaza privasyon selil timè yo nan eleman nitritif, ak enèji, ak anpeche pwodiksyon nukleotid ak asid amine, ki pwovoke otofaji, lakòz lanmò selil timè ak inibit selil. pwopagasyon. Konplèks mitokondriyo I, ki hyperactive nan selil kansè yo pou satisfè demann ogmante yo pou enèji, jwe yon wòl kle nan pwomosyon pwopagasyon selil kansè yo.
Sib: OXPHOS