IACS-010759

IACS-010759
  • Non:IACS-010759
  • Nimewo katalòg:CPDB1805
  • Nimewo CAS:1570496-34-2 (baz gratis), 1807523-99-4 (HCl)
  • Pwa molekilè:562.568
  • Fòmil chimik:C25H25F3N6O4S
  • Pou rechèch syantifik sèlman, pa pou pasyan yo.

    Pwodwi detay

    Tags pwodwi

    Gwosè pake Disponibilite Pri (USD)
    100 mg Nan Stock 300
    500 mg Nan Stock 800
    1g Nan Stock 1200
    Plis gwosè Jwenn Quotes Jwenn Quotes

    Non Chimik:

    5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) fenil)-1,2,4-oksadiazol

    Kòd SMILES:

    FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

    Kòd InChi:

    InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3

    InChi kle:

    HWJWNWZJUYCGKV-UHFFFAOYSA-N

    Mot:

    IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

    Solibilite:Soluble nan DMSO

    Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).

    Deskripsyon:

    IACS-010759 oswa IACS-10759 se yon inibitè fosforilasyon oksidatif ki pisan ak selektif (IC50).< 10 nM) ak potansyèl aktivite antineoplastic. IACS-010759 mare ak inibit konplèks I nan chèn transpò elèktron (NADH ubiquinone oxidoreductase), kidonk oaza privasyon selil timè yo nan eleman nitritif, ak enèji, ak anpeche pwodiksyon nukleotid ak asid amine, ki pwovoke otofaji, lakòz lanmò selil timè ak inibit selil. pwopagasyon. Konplèks mitokondriyo I, ki hyperactive nan selil kansè yo pou satisfè demann ogmante yo pou enèji, jwe yon wòl kle nan pwomosyon pwopagasyon selil kansè yo.

    Sib: OXPHOS


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