Omarigliptin

Non Chimik:

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H -pyran-3-amine

Kòd SMILES:

N[C@@H]1[C@@H](C2=CC(F)=CC=C2F)OC[C@H](N3CC4=NN(S(=O)(C)=O)C= C4C3)C1

Kòd InChi:

InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9) -12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+ ,17-/m1/s1

InChi kle:

MKMPWKUAHLTIBJ-ISTRZQFTSA-N

Mot:

Omarigliptin, MK-3102, MK3102, Marizev, 1226781-44-7

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

Omarigliptin, ke yo rele tou MK-3102, se yon inibitè DPP-4 ki pisan ak ki dire lontan pou tretman yon fwa chak semèn nan dyabèt tip 2. MK-3102 (omarigliptin), te idantifye kòm yon inibitè ki pisan ak selektif dipeptidyl peptidase 4 (DPP-4) ak yon pwofil farmakokinetik ekselan ki posib pou dòz imen yon fwa chak semèn epi yo chwazi kòm yon kandida devlopman klinik. Omarigliptin se kounye a nan faz 3 devlopman klinik.

Sib: DPP-4