Bardoxolone methyl

Non Chimik:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Kòd SMILES:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Kòd InChi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

InChi kle:

WPTTVJLTNAWYAO-OROHISIGSA-N

Mot:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

Sentetik oleanane triterpenoid CDDO (Atik No. 81035) se yon activator Nrf2 ki anpeche pwopagasyon ak pwovoke diferansyasyon ak apoptoz nan selil kansè divès kalite. C-28 methyl ester CDDO (CDDO methyl ester) bloke sentèz selilè sintèz nitrik oksid endizib (iNOS) ak COX-2 enduzib nan macrophages sourit INF-γ-aktive ak yon valè IC50 0.11 nM. Li pwovoke apoptoz, pwovoke diferansyasyon, ak inibit repons enflamatwa nan divès selil timè atravè anpèchman siyal IκBα kinase/NF-κB. CDDO methyl ester gen aktivite antidyabetik ki pisan, diminye ekspresyon cytokine proenflamatwa nan sourit dyabetik tip 2 ki gen anpil grès ki manje ak nan sourit Leprdb/db ak deklanche AMP-aktive pwoteyin kinaz ak aktivasyon LKB1 nan misk ak fwa.

Sib: NF-kB