MSC2530818

Lub npe tshuaj:

[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone

SMILES Code:

O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3

InChi Code:

InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0s 1

InChi Key:

ODRITQGYYWHQGM-INIZCTEOSA-N

Lo lus tseem ceeb:

MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

MSC2530818 yog lub peev xwm, xaiv, thiab Orally Bioavailable CDK8 Inhibitor nrog CDK8 IC50 = 2.6 nM; Tib neeg PK kwv yees: Cl ~ 0.14 L / H / Kg; t1/2 ~ 2.4h; F> 75%. MSC2530818 qhia zoo heev kinase selectivity, biochemical thiab cellular potency, microsomal stability, thiab hais lus bioavailable. MSC2530818 qhia tau hais tias tsim nyog potency thiab kev xaiv kom mus rau hauv preclinical hauv vivo kev ua tau zoo thiab kev tshawb fawb txog kev nyab xeeb.

Hom phiaj: CDK