TIAB SA 0187

Lub npe tshuaj:

(S)-3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl)amino)-2-((4-methoxyphenyl)sulfonamido)propanoic acid

SMILES Code:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

InChi Code:

InChI = 1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13-16-36)24-11-6-21-5-4-14-30-27(21)34-24/ h6-11,20,25,35H,4-5,12-17H2,1-3H3,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0 /s1

InChi Key:

CXHCNOMGODVIKB-VWLOTQADSA-N

Lo lus tseem ceeb:

GLPG0187, GLPG-0187, NWS 0187, 1320346-97-1

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Nyob rau hauv ib qho kev xeem-theem, GLPG0187 qhia kev xaiv rau ntau RGD integrin receptors nrog IC50s ntawm 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM rau αvβ1, αvβ3, αvβ5, αv8β6, αvβ. GLPG0187 yog ib qho muaj zog inhibitor ntawm osteoclastic pob txha resorption thiab angiogenesis. Kev kho mob nrog GLPG0187 koob tshuaj-raws li nce E-cadherin/vimentin piv, ua rau cov hlwb ntau dua epithelial, sessile phenotype. GLPG0187 koob tshuaj-dependently diminishes qhov loj ntawm aldehyde dehydrogenase siab subpopulation ntawm prostate cancer hlwb[1]. GLPG0187 kev kho mob tshwm sim hauv cell rounding thiab clumping. GLPG0187 ua kom pom qhov txo qis hauv cov qog cell migration. GLPG0187 ntawm tag nrho cov concentrations txo cov cell proliferation[2].

Lub hom phiaj: αvβ1