TIAB SA-7594

Lub npe tshuaj:

3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol -1-yl)-N-(tetrahydrofuran-3-yl)benzamide

SMILES Code:

O=C(NC1COCC1)C2=CC=CC(N3N=CC4=C3C=CC(O[C@H](C5=CC=C(OCCO6)C6=C5)[C@@H](NC(C( F)(F)C)=O)C)=C4)=C2

InChi Code:

InChI = 1S/C32H32F2N4O6/c1-19(36-31(40)32(2,33)34)29(20-6-9-2) 7-28(16-20)43-13-12-42-27)44-25-7-8-26-22(15-25)17-35-38(26)(26) 24-5-3-4-21(14-24)30(39)37-23-10-11-41-18-23/h3-9,14-17,19,2 3,29H,10-13,18H2,1-2H3,(H,36,40)(H,37,39)/t19-,23?,29-/m0/s1

InChi Key:

ZZWJKLGCDHYVMB-QMQODZDESA-N

Lo lus tseem ceeb:

AZD-7594, AZD 7594, AZD7594, AZ13189620, AZ-13189620, AZ 13189620, 1196509-60-0

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

AZD-7594, tseem hu ua AZ13189620, yog ib qho nqus tau xaiv glucocorticoid receptor (GCCR) modulator. AZD-7594 yog nyob rau theem II kev sim tshuaj los ntawm AstraZeneca rau kev kho mob ntsws asthma me me mus rau nruab nrab. Nws tseem yog nyob rau theem I kev sim tshuaj rau kev kho mob ntawm cov kab mob ntsws ntev (COPD).

Hom phiaj: GCCR